ANTI THYMOCYTE IMMUNOGLOBULIN

Brand Name & Strength

Atgam 250 mg/5 ml

Reconstitution

Not required

Further Dilution

Dilute with diluent to a maximum concentration of 4 mg/ml

Diluent

NS, QSD5, HSD5

Administration & Infusion rate

IV infusion

Administer over at least 4 hr

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

- 24 hr

Remarks

Test dose: A skin test might be needed prior to administration of the initial dose.

Dilute Atgam for intravenous infusion in an inverted bottle of sterile vehicle so the undiluted Atgam does not contact the air inside.

Atgam (diluted or undiluted) should not be shaken because excessive foaming and/or denaturation of the protein may occur. Gently rotate or swirl to mix.

Do not dilute with D5, low salt concentrations may result in precipitation.

Allow infusion solution to reach room temperature prior to administration. Infusion solution must be completed within 24 hours of preparation.

An in-line filter (pore size 0.2 to 1.0 micron) should be used during infusion to prevent the administration of any insoluble material that may develop in the product during storage.

May cause vein irritation (chemical phlebitis) if administered peripherally, high flow veins are preferred to reduce phlebitis and thrombosis.